Colossal or colossal means gigantic; enormous--
It took decades to build such a colossal edifice.
The small mistake became colossal when it went viral on the internet.
Callosal or callosal describes something related to the membrane that separates two halves of a part of the brain ( the corpus callosum, that separates the halves of the cerebrum ) --
He has some callosal damage; the doctors aren't sure he'll regain his normal capacities.
The experiment is meant to see if information can pass through the callosal membrane.
Now that you know that, you can say--
"He has a tumor in the callosal region that seems colossal, but we think we can remove it."
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